Phonetic: Abílita Bío
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THE WORD ABILITA DERIVES FROM LATIN AND MEANS “TO MAKE POSSIBLE”.
OUR COMPANY IS IN FACT FOCUSED ON DEVELOPING TECHNOLOGIES
TO ENABLE DRUG DISCOVERY AND DEVELOPMENT AGAINST CHALLENGING TARGETS LIKE
G PROTEIN-COUPLED RECEPTORS (GPCRs), ION CHANNELS, AND TRANSPORTERS.
WE ARE LEVERAGING OUR PROPRIETARY ENABLED MEMBRANE PROTEIN (EMP™) TECHNOLOGY PLATFORM
TO DRIVE THE DISCOVERY OF BIOLOGICS AND SMALL MOLECULES FOR OUR PARTNERS
AND TO FUEL OUR INTERNAL PIPELINE
WHAT IS OUR MISSION:
ENABLING DRUG DISCOVERY FOR INTRACTABLE MEMBRANE PROTEIN TARGETS, INCLUDING
G PROTEIN-COUPLED RECEPTORS, ION CHANNELS AND TRANSPORTER
Antibody Discovery
Compound Screening
Crystallography
THE MARKET FOR DRUGS TARGETING MULTI-SPAN MEMBRANE PROTEINS:
0%Of drugs in the market
$0BAnnual global revenue for GPCRs alone
>0Medically relevant MP targets identified in the human genome
0Therapeutic antibody approved worldwide
<0%Currently targeted by small molecules or peptides
>85% REMAIN UNDRUGGABLE: A TREMENDOUS UNMET MARKET OPPORTUNITY
ABILITA BIO IS JUST GETTING STARTED
THE CHALLENGE
Drug discovery targeting multi-span membrane proteins is inherently difficult due to the notoriously low stability and high conformational flexibility of these target classes, especially when removed from the cellular environment. This intrinsic characteristic of membrane proteins has greatly limited the success of protein-based small molecule screening and structure-guided drug discovery, as well as antibody discovery efforts.
OUR SOLUTION
Abilita Bio offers a technical solution through the generation of Enabled Membrane Proteins (EMPs™) for use in drug discovery and development, including antibody discovery programs. Providing enhanced full-protein antigens for antibody discovery represents a unique market opportunity, minimally available today to the Pharmaceutical Industry.